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eo771 mammary gland carcinoma cell line  (ATCC)


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    ATCC eo771 mammary gland carcinoma cell line
    a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 <t>EO771</t> cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.
    Eo771 Mammary Gland Carcinoma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 222 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/eo771 mammary gland carcinoma cell line/product/ATCC
    Average 98 stars, based on 222 article reviews
    eo771 mammary gland carcinoma cell line - by Bioz Stars, 2026-02
    98/100 stars

    Images

    1) Product Images from "αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models"

    Article Title: αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models

    Journal: Nature Communications

    doi: 10.1038/s41467-025-64296-z

    a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 EO771 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.
    Figure Legend Snippet: a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 EO771 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.

    Techniques Used: Expressing, Gene Expression, Functional Assay



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    eo771 mammary gland carcinoma cell line  (ATCC)
    98
    ATCC eo771 mammary gland carcinoma cell line
    a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 <t>EO771</t> cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.
    Eo771 Mammary Gland Carcinoma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/eo771 mammary gland carcinoma cell line/product/ATCC
    Average 98 stars, based on 1 article reviews
    eo771 mammary gland carcinoma cell line - by Bioz Stars, 2026-02
    98/100 stars
    		  Buy from Supplier

    Image Search Results


    a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 EO771 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models

    doi: 10.1038/s41467-025-64296-z

    Figure Lengend Snippet: a Kaplan–Meier survival analysis of patients with TBNC based on the effector T reg score (mean expression of FOXP3 , CTLA4 , IFNG (inverted), TNF (inverted)). Data were acquired from The Cancer Genome Atlas (TCGA) and analyzed for significance by the log-rank test. b UMAP plot of individual datasets showing distinct T reg cell populations from responders or non-responders among patients with TBNC. c Gene Ontology enrichment analysis of scRNA-seq dataset in T reg cells for non-responders vs. responders post-ICB treatment. P values were computed with a one-sided hypergeometric test and adjusted for multiple comparisons using the Benjamini–Hochberg false discovery rate (FDR). d FOXP3 gene expression of T reg cells in the scRNA-seq dataset for non-responders vs. responders. e T reg functional score (mean expression of FOXP3, TIGIT, CTLA4, IL2RA, ENTPD1, ICOS, TNFRSF9, LAG3 ) expression level of T reg cells in the scRNA-seq dataset for non-responders vs. responders. f T reg functional score expression level of T reg cells in the scRNA-seq dataset from responder (left) and non-responder (right) for post-ICB treatment vs. pre-ICB treatment. g – i 6–8 weeks old female C57BL/6 J mice were inoculated with 2 × 10 5 EO771 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( g , i ) were measured as indicated, and growth curves for each individual animal ( h ) are shown. j 33 weeks old female C57BL/6 J mice from αTIGIT-IL2 + αPD1 treated tumor free mice ( n = 2 individual animals) or 33w C57BL/6 J WT mice ( n = 2 individual animals) were inoculated with 5 × 10 5 EO771 cells. Tumor volume was measured as indicated. k , l 6–8 weeks old female Balb/c mice were inoculated with 1 × 10 5 4T1 cells. The tumor-bearing mice were administered the specified treatment intraperitoneally according to their respective groups ( n = 5 individual animals/group) on days 7, 10, and 13. Tumor volumes ( k ) were measured as indicated, and growth curves for each individual animal ( l ) are shown. Data represent mean ± SEM. The P value was determined by 2-tailed unpaired t -test ( d – f ) or 2-way ANOVA with Geisser-Greenhouse correction ( g , i , k ). Source data are provided as a Source Data file.

    Article Snippet: The CTLL-2 cytotoxic T lymphocyte cell line (TIB-214), hybridoma cells PK136 (HB-191), 293 T cell line (CRL-3216), and EO771 mammary gland carcinoma cell line (CRL-3461) were purchased from the American Type Culture Collection (ATCC).

    Techniques: Expressing, Gene Expression, Functional Assay